Analgesic and Anti-inflammatory Activity of Ficus glomerata in Experimental Animal Models

The anti-inflammatory and analgesic activity of various extracts of Ficus glomerata Roxb. were evaluated in experimental animals. We have determined the anti-inflammatory and analgesic activity of various extracts of the dried fruits of Ficus glomerata by oral administration at doses of 200 and 400 mg/kg of body weight to healthy animals. The extracts were studied for their anti-inflammatory activity in carageenan induced hind paw edema in rats and the paw volume was measured plethysmometrically after 3 hours of injection. The extracts were also evaluated for analgesic activity using Eddy’s hot plate method in mice. The extracts of Ficus glomerata significantly reduced carageenan-induced hind paw edema in rats. The extracts showed significant analgesic activity, evidenced by increase in the reaction time by the Eddy’s hot plate method in mice. The extracts showed a similar anti-inflammatory and analgesic effect compared to standard drugs indomethacin and diclofenac sodium, respectively. The present results indicated that the ethanolic extract of Ficus glomerata exhibited significantly more activity than other extracts in reducing the pain and inflammation in experimental models.